Sympathetic nerves protect the blood-brain barrier in stroke-prone spontaneously hypertensive rats.
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Sympathetic nerves protect the blood-brain barrier in stroke-prone spontaneously hypertensive rats.
Disruption of the blood-brain barrier may play a major role in the pathogenesis of hypertensive encephalopathy. In this study we determined whether sympathetic nerves to cerebral vessels protect the blood-brain barrier during chronic hypertension. We removed the cervical sympathetic ganglion on one side in 24 stroke-prone hypertensive rats when they were 1 month old. After signs of cerebral dys...
متن کاملSympathetic Nerves Protect Against Stroke in Stroke-Prone Hypertensive Rats
Studies were performed to determine whether sympathetic nerves protect against stroke in hypertensive rats. The superior cervical ganglion was removed on one side in 28 stroke-prone spontaneously hypertensive rats (SHRSP) when the rats were 4 weeks old. The rats were fed Japanese rat chow and 1% saline drinking water. When the rats were 19 weeks old, systolic pressure was 206 ± 4 mm Hg (mean ± ...
متن کاملSympathetic nerves protect against blood-brain barrier disruption in the spontaneously hypertensive rat.
108. Norberg KA, Hamberger B: The sympathetic adrenergic neuron. Acta Physiol Scandin 63 (Suppl 238), 1964 109. Dahlstrom A, Haggendal J, Hokfelt T: The noradrenaline content of the varicosities of sympathetic adrenergic nerve terminals in the rat. Acta Physiol Scand 67: 289-294, 1966 110. Bulat M, Supek Z: Mechanism of 5-hydroxytryptamine penetration through the cerebrospinal fluid-brain barrier.
متن کاملSympathetic nerves protect against stroke in stroke-prone hypertensive rats. A preliminary report.
Studies were performed to determine whether sympathetic nerves protect against stroke in hypertensive rats. The superior cervical ganglion was removed on one side in 28 stroke-prone spontaneously hypertensive rats (SHRSP) when the rats were 4 weeks old. The rats were fed Japanese rat chow and 1% saline drinking water. When the rats were 19 weeks old, systolic pressure was 206 +/- 4 mm Hg (mean ...
متن کاملStroke-Prone Spontaneously Hypertensive Rats
Background and Purpose We examined metabolic and functional changes when forebrain ischemia was induced in strokeprone spontaneously hypertensive rats by bilateral carotid artery occlusion. In addition, the protective effect of clentiazem was evaluated in this model. Methods Rats were anesthetized with urethane. Cerebral blood flow was measured with a laser Doppler fkrwmeter. Cerebral high-ener...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1982
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.4.6.904